Van de Ven Brace Halts Everton's Run at New Stadium
The Dutch defender emerged as the initial backline player to score twice in a Premier League game for Spurs since the Belgian defender in spring 2013.
At a glance
The Spurs defender heads home twice in first half
The home side's Jake O'Brien has goal disallowed after video check
Pape Matar Sarr nets third in dying moments
This loss is Everton's initial at their new ground
Micky van de Ven scored twice as Spurs prolonged their unbeaten run in away games in the top division and delivered the Toffees their initial loss at their new home.
The Toffees were undefeated in their five previous fixtures at their recently opened stadium at the dockside location, having departed Goodison Park behind after 133 years at the end of the previous campaign.
But Spurs captain Van de Ven pounced on two occasions from corners in the first half to place their impressive record at risk, and they were failed to mount a comeback before the midfielder - assisted by ex-Everton forward the Brazilian - headed home a third to put the game to bed.
Jake O'Brien thought he had equalized the scores five minutes after the defender's opener, glancing a powerful header past the Spurs keeper from an set-piece.
Beto, meanwhile, missed a number of opportunities, while Vicario made a series of fine stops to ensure the London club went five matches on the road without defeat in the Premier League.
But the VAR stepped in, advising Craig Pawson to check the goal on the pitchside monitor and the referee ruled that the winger and the attacker were in offside positions and had impeded with the Tottenham goalkeeper.
This victory moves the manager's side into third place in the Premier League, a handful of points off local foes and leaders the Gunners.
The Merseyside club remain 14th and are half a dozen points clear of the relegation zone.
Tottenham analysis: The defender fulfils role at each end of pitch
Following a drab midweek display in the Champions League against the French side, where they managed a mere two shots on target, the manager chose Randal Kolo Muani in attack instead of ex-Everton forward Richarlison.
The summer signing was failed to influence the game before being substituted for Richarlison after an hour on the field, but it emerged he wasn't needed in the end.
Defender the Dutchman transformed into an offensive threat to be reckoned with.
Tottenham's first goal came from a cleverly executed set-piece play, with Rodrigo Bentancur heading the ball back across the face of goal for an free the defender to head home.
And Ven de Ven - filling in as skipper in the Argentine's absence - notched his next goal in added time as he rose above the England keeper to head home.
Van de Ven was just as impressive in defence, combining well with Kevin Danso as the pair dealt excellently with the numerous deliveries sent their way by Everton.
Toffees breakdown: Toffees lacking finishing touch
The club's new home had been a happy hunting ground, but it seems the novelty may have worn off slightly and supporters flocked to the exits after the midfielder's third for Tottenham.
The break in Everton's unbeaten home run won't be a massive concern for the manager, but their attacking woes are.
The forward and the other striker - the Toffees' two established centre-forwards - had scored just one league goal combined before the weekend's match.
And they were unable to add to that miserable record on a wet and gloomy evening on Merseyside.
The striker's form was summed up when he opted to bicycle-kick a clear chance from close range, even with having room and opportunity to reposition for a more conventional attempt that would have challenged Vicario.
Barry, too, was unable to influence the game after coming on for the starter in the 65th minute.
It wasn't for a shortage of opportunity. The majority of Everton's offensive moves came through Grealish and Ndiaye, who relentlessly whipped dangerous crosses into the Tottenham penalty area.
What next for both teams?
The Toffees: Moyes' men head to Sunderland in the top flight on Monday, 3 November at 20:00 GMT.
Tottenham: Spurs travel to St James' Park on Wednesday, 29 October for their next round League Cup tie against Newcastle.